Skip to Main content Skip to Navigation
Master Thesis

Implication du CD95-Ligand/Fas-Ligand soluble dans les vascularites systémiques à ANCA

Abstract : ANCA associated vasculitis are inflammatory diseases affecting small blood vessels, including microscopic polyangiitis and granulomatosis with polyangiitis. Despite current treatments, their morbi-mortality remains high and unpredictable pulses can be life-threatening or lead to irreversible organ damage. There is therefore a need for new activity biomarkers as well as research for new therapeutic pathways. Soluble CD95-L is a cleaved part of CD95-L, a ligand for the CD95 cell death receptor. This s-CD95L has chemo-attractive pro-inflammatory properties on Th17 lymphocytes and neutrophils, two cell types involved in the pathophysiology of ANCA associated vasculitis. The purpose of this retrospective monocentric study, preliminary to a translational research project, was to estimate s-CD95L levels on positive ANCA sera from Bordeaux University Hospital patients and to correlate this rate with disease activity assessed by the BVAS 3.0 score. We have shown that s-CD95L is higher in patients with vasculitis and that it correlates with BVAS 3.0 score. These first elements are in favor of a role for s-CD95L in the pathophysiology of ANCA associated vasculitis. Moreover, this molecule is impaired by Ritonavir, an HIV anti-protease, and we carried out a review of the literature on the immunological mechanisms that could explain this action and the possibilities for repositioning these antiviral drugs for inflammatory and autoimmune diseases management.
Complete list of metadatas

https://dumas.ccsd.cnrs.fr/dumas-03108234
Contributor : Médecine Ub <>
Submitted on : Wednesday, January 13, 2021 - 9:29:45 AM
Last modification on : Tuesday, February 2, 2021 - 3:12:13 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2023-01-01

Please log in to resquest access to the document

Identifiers

  • HAL Id : dumas-03108234, version 1

Collections

Citation

Gaël Galli. Implication du CD95-Ligand/Fas-Ligand soluble dans les vascularites systémiques à ANCA. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03108234⟩

Share

Metrics

Record views

6