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Master Thesis

Implication du CD95-Ligand/Fas-Ligand soluble dans les vascularites systémiques à ANCA

Abstract : ANCA associated vasculitis are inflammatory diseases affecting small blood vessels, including microscopic polyangiitis and granulomatosis with polyangiitis. Despite current treatments, their morbi-mortality remains high and unpredictable pulses can be life-threatening or lead to irreversible organ damage. There is therefore a need for new activity biomarkers as well as research for new therapeutic pathways. Soluble CD95-L is a cleaved part of CD95-L, a ligand for the CD95 cell death receptor. This s-CD95L has chemo-attractive pro-inflammatory properties on Th17 lymphocytes and neutrophils, two cell types involved in the pathophysiology of ANCA associated vasculitis. The purpose of this retrospective monocentric study, preliminary to a translational research project, was to estimate s-CD95L levels on positive ANCA sera from Bordeaux University Hospital patients and to correlate this rate with disease activity assessed by the BVAS 3.0 score. We have shown that s-CD95L is higher in patients with vasculitis and that it correlates with BVAS 3.0 score. These first elements are in favor of a role for s-CD95L in the pathophysiology of ANCA associated vasculitis. Moreover, this molecule is impaired by Ritonavir, an HIV anti-protease, and we carried out a review of the literature on the immunological mechanisms that could explain this action and the possibilities for repositioning these antiviral drugs for inflammatory and autoimmune diseases management.
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Submitted on : Wednesday, January 13, 2021 - 9:29:45 AM
Last modification on : Tuesday, February 2, 2021 - 3:12:13 AM
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  • HAL Id : dumas-03108234, version 1



Gaël Galli. Implication du CD95-Ligand/Fas-Ligand soluble dans les vascularites systémiques à ANCA. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03108234⟩



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