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Master Thesis

Caractérisation phénotypique et fonctionnelle des cellules NK au cours d’un premier épisode psychotique

Abstract : The first episode of psychosis is usually followed by disorders such as schizophrenia or bipolar disorder. However, we don’t fully understand its physiopathology. The immune hypothesis, and especially the NK cells’ function is an increasing focus of interest. The aim of this work was to study the specificity of the phenotype and functional profil of NK cells during a first episode of psychosis. 39 patients were included in the Henri Mondor psychiatry center during a hospitalization for a first episode of psychosis and 32 healthy controls. Phenotypic and functional characterization of NK cells was performed in flow cytometry. We identified hyperactivated and hypofunctional NK cell profiles in patients, associated with an increase of NKG2C receptor expression. In addition, the expression of KIR2DL2 / KIR2DL3 was increased on the surface of the patients' NK cells and correlated with psychosis symptoms’ severity. Interestingly, most of these findings have been observed in patients with autism spectrum disorder and questions about common early events. It would be interesting to define patients’ serological status to understand better the phenotypic expression NKG2C, activator receptor known in the literature to be linked to CMV.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03129776
Contributor : Université Paris Descartes - Scd <>
Submitted on : Wednesday, February 3, 2021 - 9:41:31 AM
Last modification on : Wednesday, June 2, 2021 - 3:25:08 AM

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  • HAL Id : dumas-03129776, version 1

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Arthur Bouleau. Caractérisation phénotypique et fonctionnelle des cellules NK au cours d’un premier épisode psychotique. Médecine humaine et pathologie. 2019. ⟨dumas-03129776⟩

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