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Master Thesis

Survie après traitement local des métastases d’adénocarcinome pancréatique

Abstract : Introduction: the purpose of this work was to evaluate the efficacy and tolerance of local treatment of pancreatic adenocarcinoma metastases and to identify factors associated with survival.
Patients and methods: this retrospective, multi-center study, enrolled patients with metastatic pancreas ductal adenocarcinoma who received local treatment for synchronous or metachronous metastasis aimed at cure between January 2000 and December 2017.
Results: fifty-two patients in 11 French centers were enrolled between January 2000 and December 2017. Metastases were metachronous in 33 patients (63%). They were localized to liver (n = 39), lung (n = 18), ganglia (n = 6), or elsewhere (n = 6). Metastases were treated by surgery (n = 45), radiofrequency (n = 9), radiotherapy (n = 7), cryotherapy (n = 7) and microwave ablation (n = 1). The median overall survival time from the local treatment was 36.5 months. Factors associated with survival were pulmonary localization of metastases (p = 0.01), metachronous metastases (p = 0.029), N0 rather than N2 status of the primary tumor (p <0.001), and time to local treatment ≤ 6 months (p = 0.012). Time to local treatment ≤ 6 months was the only factor associated with survival without recurrence after local treatment (p = 0.002). The rate of serious complications and mortality were 4% and 3%.
Conclusion: local treatment of pancreatic cancer metastases in selected patients is safe and associated with prolonged survival. The association between time to local treatment ≤ 6 months and overall survival without recurrence is in favor of the efficacy of local treatment.
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Master Thesis
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Submitted on : Tuesday, February 16, 2021 - 4:22:05 PM
Last modification on : Thursday, September 2, 2021 - 3:09:13 AM


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  • HAL Id : dumas-03143201, version 1


Clémence Duval-Arnould Breton. Survie après traitement local des métastases d’adénocarcinome pancréatique. Médecine humaine et pathologie. 2019. ⟨dumas-03143201⟩



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