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Master Thesis

Impact du taux sérique de progestérone le jour du transfert d'embryons congelés en cycle artificiel sur le taux de grossesse évolutive

Abstract : Objective: to evaluate the impact of serum progesterone (P) level on the day of frozen-thawed embryo transfer (FET) on ongoing pregnancy rate (OPR) in artificial endometrium preparation cycles. Methods: prospective, unicentric, observational cohort study in 365 FET cycles. All patients received hormonal replacement therapy for endometrium preparation: administration of estradiol alone and then combined with administration of 600 mg/day vaginal micronized P. The threshold of 10 ng/ml was used, consistent with adequate ovulation in the literature. The P level on the day of embryo transfer was then considered as a continuous variable, allowing for a more detailed and informative analysis to evaluate its potential effect on pregnancy outcomes. Results: there was no statistically significant difference in pregnancy outcomes when progesterone levels were < 10 ng/ml or  10 ng/ml/: ongoing pregnancy rate (16.9% versus 16.6% p = 1.00), biochemical pregnancy rate (29.9% versus 32.2% p = 0.65), clinical pregnancy rate (18.2% versus 18.0% p = 1.00) and first trimester pregnancy loss rate (43.5% versus 48.5% p = 0.55). Multivariate logistic regression analysis did not identify serum progesterone level on the day of transfer as a prognostic factor statistically associated with ongoing pregnancy rate (OR: 1.00 95%CI [0.91-1.09] p = 0.96). Conclusion: no statistically significant association was found in our study between serum progesterone levels on the day of embryo transfer and OPR. Additional research is needed in the area to further characterize optimal progesterone supplementation and the role of progesterone monitoring in FET artificial cycles.
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https://dumas.ccsd.cnrs.fr/dumas-03149414
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Submitted on : Tuesday, February 23, 2021 - 9:03:37 AM
Last modification on : Saturday, February 27, 2021 - 3:10:59 AM
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Myrtille Renard. Impact du taux sérique de progestérone le jour du transfert d'embryons congelés en cycle artificiel sur le taux de grossesse évolutive. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03149414⟩

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