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Master Thesis

Troubles de la conscience au cours de la grossesse : revue systématique de la littérature

Abstract : Objective: to perform a systematic review of published case of coma during pregnancy, identify causes and prognostic factors. Study design: systematic review and meta-analysis patients and methods: search of PubMed library was performed using search terms “pregnancy”, “coma”, “consciousness disorder” and “persistent vegetative state” until studies published in December 2019. Studies were included if they mentioned at least one case of consciousness disorder in a pregnant woman and contained data relative to the patient and/or the course of the pregnancy and/or the foetus and his outcome. A good outcome was defined by survival without major handicap for women or anomaly in the development for fetuses. A univariate analysis to search prognostic factors was conducted. Results: 1321 studies were identified, 112 included in the final analysis, representing 245 pregnant woman and 248 fetuses. Coma was predominantly of neurovascular origin (31%), pre-eclampsia related (16%) or infectious (14%). Pregnancy was continued in 58% of cases. 64% of patients and 58% of fetuses had a favourable outcome. Advanced gestational age and non-neurological coma were associated with a good maternal outcome. A high Glasgow coma scale, a neurological coma, the absence of emergency caesarean section and the continuation of the pregnancy were associated with a good foetal outcome. Conclusion: this review of the literature, pooling 245 pregnant women and 248 fetuses, highlights various causes of comas (neurological or not) and possible prognosis factors.
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Master Thesis
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  • HAL Id : dumas-03154599, version 1


Jean-Baptiste Decros. Troubles de la conscience au cours de la grossesse : revue systématique de la littérature. Médecine humaine et pathologie. 2020. ⟨dumas-03154599⟩



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