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Master Thesis

Est-ce que l’usage de clips hémostatiques Hemo-Lock® au cours de la tumorectomie durant la néphrectomie partielle robot-assistée permet de réduire les saignements en toute sécurité ?

Abstract : Introduction: one challenge of Robot-assisted partial nephrectomy (RAPN) is to reduce operative blood loss. Partial nephrectomy (PN) is a complex surgery that is being made easier by robotic assistance. In this study, we determined whether the use of hemostatic clips during the tumor resection step reduced blood loss during robot-assisted partial nephrectomy.
Methods: in this retrospective study, we included all consecutive patients who underwent RAPN in our university hospital from 2017 to 2019. Three experienced surgeons performed the surgery. One surgeon used Hemo-lock hemostatic clips during tumor resection to prevent bleeding, and two did not. Blood loss in the two groups was compared as the primary endpoint. The duration of clamping, operative time, complications, surgical margins, transfusions, serum creatinine and hemoglobin were compared as secondary endpoints.
Results: fifty-three patients were included, 36 in the No-clip group and 17 in the Clip group. Our two groups were comparable for age, weight, Charlson score, tumor size and RENAL score. In univariate analysis, there was a significant difference between the two groups for median blood loss 50 mL in the Clip group versus 300 mL in the No-clip group (p = 0.0001), whereas median operating time was shorter in the No-clip group, 140 min versus 180 min for the Clip group (p = 0.044). No other criterion showed a significant difference. In multivariate analysis the use of hemostatic clips was associated with a decrease of bleeding (OR = 0,54 [0,43-0,69], p<0,0001) without altering the other major criteria such as margins status or warm ischemia time.
Discussion: the use of Hemo-lock during the tumor resection step in RAPN reduced blood loss without impairing renal function. Larger studies are still needed to confirm our findings.
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Master Thesis
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Submitted on : Thursday, March 11, 2021 - 3:45:51 PM
Last modification on : Tuesday, August 24, 2021 - 3:14:35 AM

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  • HAL Id : dumas-03166896, version 1

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Yolan Bodokh. Est-ce que l’usage de clips hémostatiques Hemo-Lock® au cours de la tumorectomie durant la néphrectomie partielle robot-assistée permet de réduire les saignements en toute sécurité ?. Médecine humaine et pathologie. 2020. ⟨dumas-03166896⟩

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