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Master Thesis

Malformations veineuses unifocales sporadiques : prise en charge dans un centre tertiaire

Abstract : Introduction: Venous malformations (VM) are rare, benign and present at birth; they grow over the life course leading to functional and esthetic impairment. Objective and methods: Retrospective study of a cohort of patients suffering from unifocal and sporadic VM, managed in the muldisciplinary consultation for vascular anomalies at the CHU of CAEN between august 2016 and august 2019. Results: 68 patients were included, 64.7% of whom were women. Pain was present in 70.6% of cases and 34.5% presented a localized consumption coagulopathy. 58.8% of patients were treated with sclerotherapy and 8.8% by surgery. Medical treatment alone was performed in 22% of cases. Recurrences after sclerotherapy were observed in 35% of patients. Conclusion: This study enabled us to confirm the chronicity and the need of a long-term follow-up of these benign malformations. The treatment is discussed according to functional impairment, mainly pain. Localized Intravascular Coagulopathy with elevated D Dimer levels is an important biomarker for the diagnosis and also for the management of these slow flow vascular malformations. Considering the chronicity of these malformations, sclerotherapy is the first-line treatment. The discovery of somatic mutations currently allows to propose a targeted therapy (sirolimus). The place of this treatment in the medical and interventional therapeutic approach has to be defined. We have proposed diagnostic and therapeutic algorithm, but these will evolve according to the European collaborative clinical studies currently in progress.
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Submitted on : Friday, March 19, 2021 - 10:42:43 AM
Last modification on : Tuesday, October 19, 2021 - 11:34:51 PM


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  • HAL Id : dumas-03174401, version 1


Pauline Lecanu. Malformations veineuses unifocales sporadiques : prise en charge dans un centre tertiaire. Médecine humaine et pathologie. 2020. ⟨dumas-03174401⟩



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