Congenital or acquired etiologies, such as cancers can lead to maxillary defects with oral-maxillofacial dysfonctions. Maxillary deficiency can be restored by surgery, prosthetically with an obturator or both. When surgery is not possible or when the patient is not agree with this solution, palatal prosthesis may offer the best solution in most clinical cases. CAD/CAM is now more widely used in many fields including removable prosthodontics, and is considered as a disruptive technology. The aim of this study is the fabrication of an individual maxillary obturator using the computer-aided design and computer-aided manufacturing (CAD/CAM) process and its clinical evaluation. Modeling softwares were used for the design, and the prosthesis was printed with a fused deposition modeling technique. The trial placement shows a satisfactory sealing and adaptation. Further studies are necessary to evaluate this kind of palatal obturator on the long term and to develop new reliable and biocompatible materials as flexible resin.