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Master Thesis

Caractérisation de l'infarctus cérébral dans le traumatisme crânien en réanimation et impact sur le pronostic à long terme : une étude prospective de cohorte

Abstract : Objectives: 1/ Assess the characteristics of cerebral infarction (CI) in traumatic brain injury (TBI) admitted in intensive cate units and identify its causes. 2/ Search a relationship between CI and long-term outcome. Study design: Monocentric observational. Patients and methods: Adults with traumatic brain injury in intensive care units (ICUs). Cerebral infarct was evoked on imaging, diagnosis and causes were confirmed by an expert panel blinded to the outcome. Long-term evolution (12 months) was assessed blinded to clinical and paraclinical data using the Glasgow Outcome Scale extended (GOS-E): a poor prognosis being defined by GOS-E ≤ 4. Infarct volumes were measured by the closest radiological images to the 21st day after TBI using semi-automated process. Cumulative total infarction volume was determined by the sum of measured infarctions. Results: 164 patients were included with 8 lost to follow-up at 12 months. Twenty-one had CI. Sequelae of intracerebral hemorrhages were the most frequent causes with 10 patients and 31% of cumulative volume. Increased cerebral pressure and its consequences had greater infarct volumes (6 patients, 42% of total). Infarct volume and 12 months outcome were related: larger volumes were associated with unfavorable outcome (p= 0,006). Conclusion: After TBI in ICUs, 13% of patients had CI. Larger volumes were linked with unfavorable outcome.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03201815
Contributor : Ufr Santé Unicaen <>
Submitted on : Monday, April 19, 2021 - 12:28:44 PM
Last modification on : Friday, April 30, 2021 - 3:31:08 AM

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  • HAL Id : dumas-03201815, version 1

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Valentin Parthenay. Caractérisation de l'infarctus cérébral dans le traumatisme crânien en réanimation et impact sur le pronostic à long terme : une étude prospective de cohorte. Médecine humaine et pathologie. 2020. ⟨dumas-03201815⟩

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