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Master Thesis

Résultats de l’AMP intraconjugale chez les hommes infertiles porteurs d’un remaniement chromosomique équilibré ou d’une microdélétion du chromosome Y

Abstract : Purpose: the aim of this study was to evaluate the ART outcomes for infertile males carrying a balanced structural chromosomal rearrangement or a Y-chromosome microdeletion, and to compare the results with a control group. The primary outcome was the clinical pregnancy rate. Methods: a retrospective case-control study has been carried out in the ART departments of the university hospitals of Bordeaux and la Réunion (South side). Results of karyotypes and Y-chromosome microdeletions analysis of infertile men with sperm concentration lower than 5 millions/mL have been extracted from the softwares Jfiv® (Bordeaux) and MédiFirst® (la Réunion). Results: the clinical pregnancy rate for carriers of balanced chromosomal rearrangements and Y-chromosome microdeletions was 27,8% and 42.9% respectively. The clinical pregnancy rate for the controls was 23.7% (non-significant difference). Conclusion: according to this study, balanced chromosomal rearrangements and Y-chromosome microdeletions are not found to affect the clinical pregnancy rate in conventional ART. Further larger scale studies are required to confirm these results.
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https://dumas.ccsd.cnrs.fr/dumas-03202339
Contributor : Médecine Ub <>
Submitted on : Monday, April 19, 2021 - 5:23:53 PM
Last modification on : Thursday, May 13, 2021 - 3:18:15 AM

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  • HAL Id : dumas-03202339, version 1

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Julian Poquet. Résultats de l’AMP intraconjugale chez les hommes infertiles porteurs d’un remaniement chromosomique équilibré ou d’une microdélétion du chromosome Y. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03202339⟩

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