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Master Thesis

Issues obstétricales et néonatales après fécondation in vitro chez les patientes obèses

Abstract : Introduction: Obesity is a public health problem with an increase in obstetric and neonatal complications. At the same time, IVF techniques also increase obstetrical and neonatal risks. The aim of this study is to compare the obstetrical and neonatal outcomes of obese patients with induced pregnancy by IVF compared to obese patients who had a spontaneous pregnancy. Materials and methods: All patients who gave birth in the Caen CHU between the 1st of January in 2011 and the 31st of December in 2017 were included retrospectively. We used propensity scores to compare our two groups. Results: 2,630 patients with a BMI greater than 30 kg/m² were included in this study with a median BMI of 33 kg/m² for the IVF group and 34 kg/m² for the non-IVF group. The unmatched analysis between IVF and non-IVF pregnancies found no significant difference for obstetric and neonatal outcomes. After matching, the risk of induction of labor is higher with an OR of 2.14 [95% CI 1.05 - 4.37] in IVF patients. The risk of neonatal hospitalization was also higher with an OR of 3.0 [95% CI 1.07 - 8.43]. Conclusion: The impact of IVF for obese patients is not significant for obstetric outcomes except for labor induction. The risk of hospitalization in neonatal intensive care is increased. Transversal management of these couples undergoing ART is essential. An information on the risks associated with pregnancy and neonatal outcome in relation to maternal obesity and the IVF procedure must be explained.
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Submitted on : Wednesday, April 21, 2021 - 12:44:33 PM
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  • HAL Id : dumas-03204163, version 1


Camille Vatelot. Issues obstétricales et néonatales après fécondation in vitro chez les patientes obèses. Médecine humaine et pathologie. 2020. ⟨dumas-03204163⟩



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