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Master Thesis

Les tumeurs borderline de l’ovaire de stade avancé : facteurs pronostiques et place du traitement conservateur

Abstract : Background: the aim of this study was to assess prognostic factors and conservative treatment in patients with stage II or III serous borderline ovarian tumors (SBOT) after a long term follow up in a large series. Methodology: patients with SBOT and peritoneal implants treated or referred to our institution were retrospectively reviewed. Results: between 1971 and 2017, 212 patients were identified. 33 had invasive implants. After a median follow up of 115 months, 70 recurrences were observed, 28 of them under the form of invasive disease. Disease-free survival (DFS) at 5 and 10 years were 73% and 62% respectively. Invasive implants were not associated with DFS (HR=1.39[0.77-2.51], p=0.27) nor Overall Survival (OS) (HR=1.76[0.57-5.47], p=0.32). Radical surgery (HR=7[2.35-20.87], p=0.0002), invasive implants (HR=5.37[1.29-22.26], p=0.013), and 3 or more peritoneal sites (HR=3.56 [1.11-11.39], p=0.024) were identified as predictors of recurrence in the form of invasive disease. 65 patients were treated conservatively, the recurrence rate was high (58%). Conclusion: this study demonstrates that after a long term follow up, type of peritoneal implants is no longer a prognostic factor on overall survival. Implants on at least three peritoneal sites seems to impact significantly the risk of recurrence under the form of invasive disease and overall survival requiring then a specific follow-up in this subgroup of patients. Furthermore, the conservative treatment of advanced stage SBOT (with noninvasive implant) can be cautiously achieved to preserve the possibility of pregnancy but the recurrence rate is high.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03205365
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Submitted on : Thursday, May 6, 2021 - 3:53:27 PM
Last modification on : Tuesday, September 7, 2021 - 3:23:50 AM

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  • HAL Id : dumas-03205365, version 1

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Sophie Maria. Les tumeurs borderline de l’ovaire de stade avancé : facteurs pronostiques et place du traitement conservateur. Médecine humaine et pathologie. 2019. ⟨dumas-03205365⟩

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