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Master Thesis

Acute hemolytic anemia caused by G6PD deficiency in children in Mayotte: a frequent and severe complication

Abstract : Background : Severe hemolytic anemia is a rare complication of Glucose-6 Phosphate dehydrogenase (G6PD) deficit. It is described in Mediterranean variant corresponding to severe G6PD activity deficit according to the WHO classification. In Mayotte, the majority of patients are African variant with moderate deficit activity. Yet we observe a lot of severe hemolytic anemia defined by a hemoglobin rate lower than 6 g/dL. In this study, we aimed to describe the epidemiological, clinical, biological and treatment of children, presenting severe hemolysis crisis secondary to G6PD deficiency in Mayotte. The secondary objective was to study genotype when it was available. Method : A retrospective collection of children with severe hemolytic anemia related to G6PD deficiency hospitalized in Mayotte hospital from April 1st 2013 to September 16th of 2020 was made. Results : 73 children had severe anemia due to G6PD deficit in Mayotte. The median of hemoglobin during hemolysis crisis was 3.9 g/dl. All patients benefited for a transfusion and hospitalization. Twenty patients had a genotype: eleven had African mutation and 9 had a Mediterranean mutation. Discussion : Among the most common triggers of G6PD acute hemolysis anemia, drugs were not present and fava bean ingestion was found in only one child. One of the particular triggers was traditional medicine, including Acalypha Indica. Severe hemolysis crisis of children due to G6PD deficiency is frequent in Mayotte. Patients are more serious, and severity is not correlated with genotype: African (A-) variant and Mediterranean variant have the same gravity.
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Master Thesis
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Submitted on : Friday, August 20, 2021 - 6:22:56 AM
Last modification on : Wednesday, November 3, 2021 - 4:30:28 AM
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  • HAL Id : dumas-03322907, version 1


Marie Boyadjian. Acute hemolytic anemia caused by G6PD deficiency in children in Mayotte: a frequent and severe complication. Life Sciences [q-bio]. 2020. ⟨dumas-03322907⟩



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