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Master Thesis

Les thérapeutiques médicamenteuses en fin de vie en oncologie : étude rétrospective au GHM de Grenoble en 2018

Abstract : Oncology implies the notion of end of life, accompanying the patient towards end of life care and confronting the use of medications realistically, in a health system with budgetary constraints and difficult decisions. The inventory of drug therapies available in oncology and used towards the end of life and the estimation of their cost is an important step contributing to the optimization of the management of patients at the end of life. A descriptive retrospective survey was carried out in 2018 at the Grenoble Mutualist Hospital Group, gathering the use of drug therapies and their costs during the last three months of life prior to death, with a focus on the last month of life. The secondary objectives were to expose potentially inappropriate drug use, to assess whether recommendations had been followed and to evaluate the use of a palliative approach. Of the 228 records analyzed, 44% of patients received injectable chemotherapy in the last three months, 23% in the last month. The overall cost of the cytotoxics administered during the study period was €170,347, 97% of which concerned expensive injectable molecules. The use of cytotoxics in relation to their performance score deviated from the recommendations of the learned societies. In oncology, Evidence-Based Medicine is confronted with the human component when making end-of-life decisions, and concerns both the patient and the healthcare professional(s). The participation of a pharmacist in multi-professional decisions would make it easier to guarantee the proper use of drug therapies.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Friday, September 10, 2021 - 9:08:56 AM
Last modification on : Sunday, September 12, 2021 - 3:16:24 AM
Long-term archiving on: : Saturday, December 11, 2021 - 6:02:06 PM


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  • HAL Id : dumas-03332228, version 1
  • PPN : 249095203


Cécile Auger. Les thérapeutiques médicamenteuses en fin de vie en oncologie : étude rétrospective au GHM de Grenoble en 2018. Sciences pharmaceutiques. 2020. ⟨dumas-03332228⟩



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