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Master Thesis

Are lupus patients characterized by a phenomenon of accelerated aging? Analysis of literature and pilot study on epigenetic biomarkers of age.

Abstract : Thanks to improvements in diagnosis, therapeutics and medical care, lifespan of systemic lupus erythematosus (SLE) patients has remarkably increased over the last decades. However, mortality ratio are still high in this population. Some clinical manifestations, more commonly found during old age in the general population such as cardiovascular events, cancers or infections, appear frequently at a younger age, raising the question of the presence of an acceleration of the aging process in SLE patients. In the first part of this work, we reviewed and compared literature evidence on the seven pillars of aging (i.e. macromolecular damage, metabolism, stem cells, proteostasis, adaptation to stress, inflammation and epigenetics) evaluated in SLE patients, and explored possible interconnections between these two frameworks. In the second part of this work, we applied DNA methylation biomarkers, which are the most robust biomarkers of age developed so far, in publicly available datasets of SLE patients. We included in our analysis two distinct DNA methylation datasets of 30 and 55 subjects respectively. For every SLE patient and control, we calculated their epigenetic age and a measure of epigenetic age acceleration, according to Horvath’s epigenetic clock model. We did not observe any evidence of an accelerated biological aging according to this measure in SLE patients, as there was no statistically significant difference in the measure of epigenetic age acceleration between SLE patients and controls.
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https://dumas.ccsd.cnrs.fr/dumas-03351583
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Submitted on : Wednesday, September 22, 2021 - 2:31:53 PM
Last modification on : Friday, October 22, 2021 - 3:44:44 AM

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  • HAL Id : dumas-03351583, version 1

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Noémie Gensous. Are lupus patients characterized by a phenomenon of accelerated aging? Analysis of literature and pilot study on epigenetic biomarkers of age.. Life Sciences [q-bio]. 2021. ⟨dumas-03351583⟩

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