HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Master Thesis

Six months results on efficacy, safety, and optical coherence tomography monitoring of the bleb, following Preserflo MicroShunt™ implantation

Abstract : Purpose: To evaluate anatomical characteristics of the filtering blebs and scleral wall thickness using anterior segment optical coherence tomography after ab externo Preserflo MicroShunt™ micro-invasive glaucoma surgery (MIGS) with mitomycin C application as well as efficacy and safety of the microshunt. Methods: Single-site, prospective, interventional case series conducted in a tertiary university hospital. Open-angle glaucoma patients underwent ab externo Preserflo MicroShunt™ implantation with 0.4 mg/ml MMC sponge application. Anterior segment OCT of the filtering bleb and the underlying scleral wall were performed pre-operatively and 1 week, 1, 3, and 6 months post-operatively. Results: Fourteen eyes of 14 patients were included. IOP was significantly reduced from a mean preoperative value of 19.7 ± 10.1 mmHg to a mean postoperative value of 13.2 ± 8.8, 7.9 ± 2.8, 12.25 ± 4.5, 16.7 ± 8.5, and 15.3 ± 7.2 mmHg at 0 (p<0.001) and 7 days (p<0.001), and 1 (p=0.014), 3 (p=0.02) and 6 months (p=0.012), respectively. Glaucoma medications number were also significantly reduced (p<0.01 for all values) from 3.2 ± 0.7 pre-operatively to 0, 0, 0.2 ± 0.7, 0.5 ±1.1 at day 7 and 1, 3 and 6 months, respectively. No major postoperative complications were reported. Needling of the bleb was performed post-operatively in 1 eye (7.1%). The proportion of subjects with IOP decrease > 20% at month 6 compared to baseline was significantly higher in patient with high bleb height (p=0.02) and high distance between the implant and the conjuctiva (p=0.01), but was not related to the presence of subconjunctival or subtenon fluid, the presence of subconjunctival cysts nor the bleb tissue hyporeflectivity (p>0.1) Conclusions: We found significant and comparable results in terms of efficacy and safety with the Preserflo MicroShunt™ compared to previous studies. Anterior-segment OCT imaging showed similar macroscopic characteristics of functional blebs in most of the patients.
Document type :
Master Thesis
Complete list of metadata

https://dumas.ccsd.cnrs.fr/dumas-03369847
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Thursday, October 7, 2021 - 3:56:58 PM
Last modification on : Wednesday, November 3, 2021 - 6:56:50 AM
Long-term archiving on: : Saturday, January 8, 2022 - 7:24:36 PM

File

2020GRAL5167_allaix_kevin_dif....
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-03369847, version 1

Citation

Kévin Allaix. Six months results on efficacy, safety, and optical coherence tomography monitoring of the bleb, following Preserflo MicroShunt™ implantation. Human health and pathology. 2020. ⟨dumas-03369847⟩

Share

Metrics

Record views

34

Files downloads

13