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Master Thesis

Comparaison du devenir après radiothérapie ablative stéréotaxique des patients souffrant d’une tumeur pulmonaire primitive versus une tumeur métachrone

Abstract : Introduction: early-stage lung cancer, whose management relies on parenchymal resection surgery, is in nearly a quarter of cases not operable (impaired respiratory function , prior thoracic surgery, severe comorbidities). Stereotactic ablative radiotherapy (SABR) is a non-surgical alternative that provides radical local treatment. This technique, particularly relevant in resectable but nonoperable tumors, is poorly evaluated in metachronous lung tumors.
Objective: the objective of this study is to evaluate the clinical outcome of patients treated with SABR for metachronous lung tumor versus primary stage I lung tumor.
Material and methods: 137 patients treated with SABR for stage I non-small cell lung carcinoma were retrospectively included, of whom 28/137 were treated for stage I metachronous tumor and 109/137 for stage I primary lung tumor. Clinical follow-up, overall survival, recurrence-free survival, metastasis-free survival, tumor control, toxicities, and dosimetry were collected.
Results: after SABR, patients treated for metachronous lung tumor have survival comparable to that of patients treated for stage I primary lung tumor, with no significant increase in the rate of severe toxicities. SABR is a relevant approach to treat localized metachronous lung tumors, especially in unoperable patients.
Document type :
Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03371240
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Submitted on : Friday, October 8, 2021 - 2:33:47 PM
Last modification on : Tuesday, December 7, 2021 - 4:10:59 PM
Long-term archiving on: : Sunday, January 9, 2022 - 7:49:30 PM

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2021NICEM075.pdf
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  • HAL Id : dumas-03371240, version 1

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Jonathan Benzaquen. Comparaison du devenir après radiothérapie ablative stéréotaxique des patients souffrant d’une tumeur pulmonaire primitive versus une tumeur métachrone. Médecine humaine et pathologie. 2021. ⟨dumas-03371240⟩

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