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Master Thesis

Critères histopronostiques et altérations de la voie RASSF/Hippo dans la carcinogenèse colique

Abstract : Colorectal carcinogenesis results from several mechanisms of genetic and epigenetic alterations, including alteration of the RASSF/Hippo pathway, by hyperméthylation of gene's promoter involved in this pathway. The objectives of our study were to analyze the impact of histopronostic factors, as well as the methylation status of genes in RASSF/Hippo pathway on the survival of patients with colic cancer. Methylation status was investigated by Methyl Specific PCR. Survival was studied using Kaplan-Meier curves, and a Cox regression model was used to identify prognostic factors for overall and free recurrence survival. Our results show a poor prognosis of infiltrating type of tumor invasion mode and presence of isolated tumor deposits. A highgrade budding shows a tendency to poor prognosis, with no significant difference. The methylation study of RASSF/Hippo members shows that RASSF2 promoter is frequently methylated in colic cancer (86.9%), and that patients have poorer survival when methylated. The analysis of recent histoprognostic factors such as invasion mode, tumor deposits and budding could be integrated into the results of anatomo-pathological examinations, as they have a prognostic impact. The study of the methylation status of RASSF2 may also be a prognostic factor for clinical practice in the future.
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Master Thesis
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Submitted on : Wednesday, October 13, 2021 - 4:25:31 PM
Last modification on : Thursday, October 21, 2021 - 5:02:32 AM
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  • HAL Id : dumas-03376727, version 1


Marc Riffet. Critères histopronostiques et altérations de la voie RASSF/Hippo dans la carcinogenèse colique. Médecine humaine et pathologie. 2021. ⟨dumas-03376727⟩



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