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Master Thesis

Stimulation ovarienne par de la corifollitropine alpha versus FSH quotidienne chez les donneuses d'ovocytes : efficacité et vécu

Abstract : Objectives: To demonstrate that ongoing pregnancy rate is equivalent between corifollitropin alfa and daily FSH. Compare the clinical and biological criteria, tolerance and satisfaction of oocyte donors. Materials and methods: From January 2014 to December 2019, 105 donations were analyzed from a cohort of 96 oocyte donors: 81 in daily FSH and 24 in the corifollitropin alfa group. The population was comparable except for the significantly lower AMH in the corifollitropin alfa group. Tolerance and satisfaction were assessed by a telephone questionnaire. Results: The duration of stimulation, the total number of oocytes retrieved and in metaphase II were equivalent. The fertilization rate was significantly higher in the corifollitropin alfa group (86.4% vs 76.4%, p=0.02), as was the total number of embryos per donation (11.8±6.39 vs 8.30±5.34, p=0.02). Ovarian hyperstimulation syndrome incidence was higher in the corifollitropin alfa group (17% vs 9.9%, p=0.46). Ongoing pregnancy rate was not different. The donation experience and the short and long term effects were similar. The major constraint on donation was the organization of stimulation monitoring for more than half of the women. Conclusion: Corifollitropin alfa offers equivalent efficacy with encouraging results in terms of number of embryos and ongoing pregnancies. Ovarian hyperstimulation syndrome incidence is higher among its users. Reducing monitoring is a line of thought to improve the comfort of donors.
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https://dumas.ccsd.cnrs.fr/dumas-03381890
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Submitted on : Monday, October 18, 2021 - 9:27:06 AM
Last modification on : Thursday, October 21, 2021 - 5:02:32 AM

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  • HAL Id : dumas-03381890, version 1

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Clémence Beaussire. Stimulation ovarienne par de la corifollitropine alpha versus FSH quotidienne chez les donneuses d'ovocytes : efficacité et vécu. Médecine humaine et pathologie. 2021. ⟨dumas-03381890⟩

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