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Master Thesis

Entérocolite ulcéro-nécrosante : incidence, facteurs de risque et devenir étude cas-témoins

Abstract : Background: necrotizing enterocolitis (NEC) is the most common gastrointestinal disease in preterm neonates. Regarding high mortality, digestive and neurological morbidity, prevention of NEC has to be a top priority
Objectives: we aimed to investigate prenatal and neonatal risk factors (RF) and pronostic factors of NEC.
Methods: monocentric retrospective case-control study in one neonatal intensive care which explored each case of NEC between 2015 et 2018. Cases were matched with controls for sex, term, and birth weight.
Results: a total of 72 cases (group C) and 144 controls (group T) were enrolled in the study. The NEC incidence was 3.85% with a significant proportion of very low birth weight (VLBW). Less mechanical ventilation and surfactant therapy in the group C. Less exposure of the group C to antibiotics in pre- and post-natal care. No significant difference in hemodynamic and nutritional parameters. Same results in the very premature infants but with later and more severe forms. Severity factors: more immature (less than 28 GA), VLBW, prior respiratory distress.
Discussion: VLBW appears to be a major RF and severity factor. Few other factors are significantly different. In the more immature: different clinical picture and more severe clinical features. NEC is a complex and multifactorial pathology; the power of the study is insufficient.
Conclusion: our study showed that the main factor of NEC is VLBW. Induced prematurity due to placental insufficiency could favour NEC.
Document type :
Master Thesis
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Submitted on : Friday, November 5, 2021 - 4:05:11 PM
Last modification on : Friday, August 5, 2022 - 2:43:21 PM
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  • HAL Id : dumas-03387858, version 1


Adelaïde Brunet. Entérocolite ulcéro-nécrosante : incidence, facteurs de risque et devenir étude cas-témoins. Médecine humaine et pathologie. 2020. ⟨dumas-03387858⟩



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