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Master Thesis

Évaluation des pratiques de supplémentation en vitamine B12 en post-chirurgie bariatrique dans les centres spécialisés de l'obésité et élaboration d'un protocole d'étude comparant l'administration de vitamine B12 per os et intramusculaire

Abstract : Introduction: There is still a significant risk of vitamin B12 deficiency associated with widespread bariatric surgery. It might results in irreversible neurological repercussions. The current clinical practices guidelines are unclear and even some recommendations are discordant. The treatment historically used remains repeated intramuscular injection in spite of its drawbacks. Nevertheless, more and more studies supported the efficiency of the oral route. Our main objective is to compare the effectiveness of these two treatment routes. Methods: We sent a survey to 37 French specialized obesity centers on vitamin B12 supplementation in postbariatric surgery patients to draw an assessment of current practices. Results: 41 physicians from 29 specialized obesity centers answered the survey. It highlighted a great diversity of supplementation practices, with a trend to foster the oral route. Using the results of this survey and the data already present in the literature, we developed a study protocol with the objective of proving the non-inferiority of the oral route compared to the intramuscular one. Conclusion: We developed a study protocol in order to support future guidelines and to lower the risk of a potential B12 deficiency in this increasingly numerous operated population. Further studies will be needed to substantiate the recommendations.
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https://dumas.ccsd.cnrs.fr/dumas-03585454
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Submitted on : Wednesday, February 23, 2022 - 10:42:28 AM
Last modification on : Thursday, February 24, 2022 - 3:29:59 AM

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  • HAL Id : dumas-03585454, version 1

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Hugo Pisaroni. Évaluation des pratiques de supplémentation en vitamine B12 en post-chirurgie bariatrique dans les centres spécialisés de l'obésité et élaboration d'un protocole d'étude comparant l'administration de vitamine B12 per os et intramusculaire. Médecine humaine et pathologie. 2021. ⟨dumas-03585454⟩

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