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Master Thesis

Étude du biomarqueur sérique sTREM-1 dans la polyarthrite rhumatoïde et la fièvre méditerranéenne familiale

Abstract : Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) is a pro-inflammatory cell surface receptor expressed mainly on monocytes and neutrophils. The objective was to determine whether the serum level of the soluble form of TREM-1 (sTREM-1), which reflects TREM-1 activation, was associated with disease activity in rheumatoid arthritis (RA), a model of polygenic autoimmune disease and familial Mediterranean fever (FMF), a model of rare autoinflammatory disease associated with MEFV mutations. We also investigated whether sTREM-1 could predict the response to biologics in RA. In RA, we conducted an ancillary study of the French national ROC (NCT01000441) trial in which 300 RA patients with an inadequate response to a 1st line anti-TNF agent were randomized to switch to either a 2nd anti-TNF or a non-anti-TNF agent. Serum sTREM-1 level was assessed in 272 patients with available serum samples at baseline. sTREM-1 was correlated to RA disease activity score but also to specific disease activity features such synovitis and patient global. sTREM-1 was not predictive of treatment response. In the FMF population, sTREM-1 was assessed in 56 patients followed at the French National FMF Centre. sTREM-1 was not associated with clinical or biological features of disease activity but was significantly higher in patients with AA amyloidosis, the most serious complication of FMF. These data suggest an interesting involvement of the TREM-1 pathway in the pathophysiology of these two inflammatory diseases.
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Master Thesis
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Submitted on : Wednesday, March 9, 2022 - 4:10:29 PM
Last modification on : Saturday, April 2, 2022 - 3:34:23 AM


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  • HAL Id : dumas-03603076, version 1


Clémence Tawil Gorlier. Étude du biomarqueur sérique sTREM-1 dans la polyarthrite rhumatoïde et la fièvre méditerranéenne familiale. Médecine humaine et pathologie. 2019. ⟨dumas-03603076⟩



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