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Master Thesis

Le Diagnostic préimplantatoire : incidence de la biopsie des cellules embryonnaires sur le déroulement de la grossesse et l'état néonatal

Abstract : Since the first preimplantatory diagnosis (PGD) procedure in 1990, indications have regularly increased. The follow up of children born after PGD show no adverse outcomes but no studies have been reported concerning the pregnancy and possible complications related to PGD procedure. This retrospective study aimed at comparing obstetrical and neonatal outcomes in 86 singleton pregnancies obtained after ICSI/PGD versus 115 singleton pregnancies obtained after ICSI. Patients characteristics were not significantly different excepted for gestity and parity which were higher in the PGD group. The rates of maternal hospitalisation, premature labour, and gestational diabetes were significantly higher in the ICSI group (23.3% versus 12.8%, 13.9% versus 4.6% et 10.4% versus 1.2%, p<0.005 respectively). Patients of PGD group had higher rates of first trimester bleeding, praevia placenta, and preeclampsia without reaching the statistical significance. Birth weights, term delivery, and delivery modalities were similar in both groups. Néonatal hospitalisations were observed more often in the PGD group without reaching the statistical significance. Pregnancies obtained after ICSI/PGD procedures don't seem to be considered as high risk pregnancies as compared to ICSI pregnancies.
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Submitted on : Wednesday, February 9, 2011 - 4:29:49 PM
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  • HAL Id : dumas-00564681, version 1

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Mandy Frayssinet. Le Diagnostic préimplantatoire : incidence de la biopsie des cellules embryonnaires sur le déroulement de la grossesse et l'état néonatal. Gynécologie et obstétrique. 2010. ⟨dumas-00564681⟩

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