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Master Thesis

Le potentiel de tératogénicité des statines et fibrates : revue de la littérature et étude à partir d'un cas clinique déclaré au centre régional de pharmacovigilance de Grenoble

Abstract : The choice to continue treatment with lipid-lowering agent during pregnancy becomes an issue more and more prevalent in our society. Indeed, the lipid changes during pregnancy and the occurrence of dyslipidemia can be a gestational complication during pregnancy. Moreover, the occurrence of cardiovascular disease or cardiovascular risk factors increases in women of childbearing age. In this work, we evaluate the potential teratogenicity of statins and fibrates to data from the literature on animal and human exposures and on national notifications of all regional centers of drug monitoring centre (pharmacovigilance). In a second step, we propose methods of care in a woman who wants to begin a pregnancy or in a woman whose pregnancy was unknown and exposed to a lipid-lowering agent.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00593285
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Submitted on : Friday, May 13, 2011 - 5:41:30 PM
Last modification on : Wednesday, July 15, 2020 - 8:56:03 AM
Long-term archiving on: : Sunday, August 14, 2011 - 3:15:41 AM

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  • HAL Id : dumas-00593285, version 1

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Marjorie Puthot. Le potentiel de tératogénicité des statines et fibrates : revue de la littérature et étude à partir d'un cas clinique déclaré au centre régional de pharmacovigilance de Grenoble. Sciences pharmaceutiques. 2011. ⟨dumas-00593285⟩

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