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Master Thesis

La dengue : un vaccin à l'horizon 2015

Abstract : Dengue is a recent disease in human history, but its strong expansion in recent decades (in 2008, experts estimated that 40% of the world population is exposed), makes of this arbovirose a major problem of public health. While the disease is expressed weakly in most cases (or in the form of a simple fever), dengue gives more and more severe disease with vascular leakage and hemorrhage. The explosion of cases in epidemics has led health authorities to develop effective control measures against dengue. The search for a vaccine has become a priority. The characteristics of the disease, the presence of four serotypes, the role of the immune response in the pathogenesis, the lack of animal models are the difficulties that laboratories have to face. Despite these problems a panel of vaccine candidates including live attenuated vaccines, chimeric vaccines, inactivated vaccines and naked DNA vaccine, vectored vaccine or finally replication incompetent vaccine. Of these, some are at different stages of clinical development is well advanced, the chimeric vaccine VJF17D of Acambis / Sanofi-Pasteur has established itself as the current leader. It entered into clinical phase III, and could be marketed by 4 or 5 years.
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Master Thesis
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Submitted on : Tuesday, August 16, 2011 - 1:31:53 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
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  • HAL Id : dumas-00614768, version 1
  • PPN : 154160911


Jean-François Leorat. La dengue : un vaccin à l'horizon 2015. Sciences pharmaceutiques. 2011. ⟨dumas-00614768⟩



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