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Master Thesis

Artère pulmonaire et ventricule droit dans l'hypertension pulmonaire‎ : corrélation entre la TDM synchronisée à l'ECG et le cathétérisme cardiaque droit

Abstract : Purpose: To retrospectively investigate whether a relationship exists between ECG-gated-CT functional parameters (right ventricular ejection fraction (RVEF), right ventricular cardiac output (RVCO), pulmonary artery (PA) distensibility) and mean pulmonary arterial pressure (mPAP) or CO measured by right-side heart catheterization (RHC) in patients with pulmonary hypertension. Materials and Methods: This retrospective study was submitted to the institutional review board, patient consent was not required. Twenty-seven patients with PH who had undergone both ECG-gated-CT and RHC were included. Two independent observers, blinded to RHC results, measured on ECG-gated-CT: PA diameter, PA distensibility, aorta diameter, RVCO and RVEF with two methods: automatic segmentation and Simpson technique. CO and mPAP were measured on RHC. The relationship between ECG-gated-CT and RHC measurements were tested with linear regression analysis. Results: Interobserver agreement was good for all measurements (R>0.7) except for RVCO calculated with Simpson's technique (R=0.63). PA distensibility was significantly correlated to mPAP (r=-0.426, p=0.027). RVEF was correlated with mPAP only when issued from Simpson technique (r=-0.417, p=0.034). RVEF was not significantly correlated to CO, whether with segmentation or Simpson technique (p>0.2). RVCO measured with Simpson technique (r=0.487, p=0.010) and automatic segmentation (r=0.549, p=0.005) correlated equally with CO measured with RHC. Conclusion: RVEF and RVCO measured on ECG-gated-CT are significantly correlated respectively to mPAP and CO measured on RHC and could be useful for staging and follow up of patient with PH.
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Master Thesis
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  • HAL Id : dumas-00626806, version 1

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Élodie Abel. Artère pulmonaire et ventricule droit dans l'hypertension pulmonaire‎ : corrélation entre la TDM synchronisée à l'ECG et le cathétérisme cardiaque droit. Médecine humaine et pathologie. 2011. ⟨dumas-00626806⟩

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