This dissertation aims at analyzing and explaining the challenges of interpretation of House of Leaves. By commenting precise examples, we have highlighted a major thematic of the novel, implicit and yet duplicated within every layer of narration. We concentrated first on the function of mythology in the novel and then moved on to a study of the trope of the labyrinth ; through these two examples, we uncovered the devices of the personal quests of the characters. Seeking to come terms with a traumatic past, their means to move on is by transposing the painful memory unto another subject. Complex and confusing, House of Leaves leads the reader into a maelstrom of words - at times merely absurd or nonsensical - turning the reading into a laborious experience. The reader is ironically starting into a laborious experience. The reader is ironically starting a quest of his own imitating the characters he reads about. Undoubtedly, Danielewski brings us to a constructive metafictional reflection by going this far into the possibilities offered by print books in a time of digital hegemony.