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Master Thesis

Maturation cervicale à terme par le misoprostol : étude prospective réalisée au centre hospitalier universitaire de Bordeaux

Abstract : Objective: The objective is to evaluate the efficacy and safety of a 25 microgram vaginal capsule in cervical ripening and labour induction. Materials and Methods: It's a prospective study in the maternity hospital of Bordeaux between May and August 2011. The nulliparous and multiparous women with a singleton pregnancy in presentation cephalic without antecedent of caesarean section were eligible for the induction of labour. The patients receive doses of 25 g into the posterior fornix of the vagina every 4 hours until the obtaining of a working dynamic. The primary outcome measure was the time of the vaginal deliveries, the number achieved within 24 hours of the start labour induction and the fetal safety. Secondary outcome measures included caesarean sections and instrument-assisted vaginal deliveries. Results : A total of 60 women were included. 88,33% (n=53) of the population gave birth within 24 hours of induction and we had 1 case of caesarean section deliveries. 10% (n=6) of the birth was instrumental deliveries. Conclusion : In conclusion low-dose misoprostol every 4 hours is efficacious in cervical ripening and labour induction and demonstrates a good maternal and fetal safety but the study is to small to assert the security of using misoprostol in obstetric.
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https://dumas.ccsd.cnrs.fr/dumas-00717192
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Thursday, July 12, 2012 - 11:08:34 AM
Last modification on : Wednesday, August 23, 2017 - 4:40:18 PM
Long-term archiving on: : Thursday, December 15, 2016 - 10:18:55 PM

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Anne-Charlotte Fremy. Maturation cervicale à terme par le misoprostol : étude prospective réalisée au centre hospitalier universitaire de Bordeaux. Gynécologie et obstétrique. 2012. ⟨dumas-00717192⟩

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