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Master Thesis

Involvement of high frequency oscillations ranging from 60 to 100Hz at seizure onset demonstrated with epileptogenicity maps‎ : new insights into seizure onset zone definition

Abstract : High gamma oscillations (HFO, >60 Hz) at seizure onset are strongly associated to epileptogenesis, and their localising value for the seizure onset zone (SOZ) has been underlined using quantitative measures such as the epileptogenicity index. In particular, we recently reported a new method that produces images of epileptogenicity based on the detection of significant increase of HFO at seizure onset in stereotactic coordinates derived from patient's MRI (magnetic resonance imaging). Here, we applied the same analysis to 21 consecutive patients who underwent stereo-electroencephalography (SEEG) recordings between 2009 and 2011, and in whom at least one spontaneous seizure was recorded. Power of HFO ranging from 60 to 100Hz band (ictalHFO60-100) was quantified at onset for each seizure, and statistical parametric maps were used to represent the cortex areas displaying significant ictalHFO60-100 when compared to an interictal baseline. Analysis was performed at the patient level per seizure, with a group analysis for every patient. All patients presented a significant epileptogenicity map at seizure onset, whatever seizure onset location or histological lesion they had. IctalHFO60-100 map was highly reproducible over seizures per patient, and most significant ictalHFO60-100 had the same localisation as epileptogenic lesions. For 11 patients who underwent a 3DT1 MRI in the post-operative period, the removal of cortex areas displaying ictalHFO60-100 was associated to a better outcome. Epileptogenicity map is useful to evaluate the SOZ in the pre-surgical period. This new tool associated to SEEG might help to improve the surgical outcome of medically-intractable epilepsies.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00732973
Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, September 17, 2012 - 3:00:15 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Friday, December 16, 2016 - 2:13:18 PM

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  • HAL Id : dumas-00732973, version 1

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Anne-Sophie Job. Involvement of high frequency oscillations ranging from 60 to 100Hz at seizure onset demonstrated with epileptogenicity maps‎ : new insights into seizure onset zone definition. Human health and pathology. 2012. ⟨dumas-00732973⟩

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