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Master Thesis

Administrations parentérales en unité d'hématologie soins intensifs‎ : incompatibilités physico-chimiques et optimisations

Abstract : Each drug has self physical and chemical properties because of its active molecule and its excipients. This is particularly relevant talking about parenteral drugs. Any contact between two drugs makes the physicochemical incompatibility risk become real. AIMS : This study will observe the nurse practices and habits and will evaluate the extent of the compatibility problem in the intensive care unit of hematology of Grenoble. Finally, in order to help reducing the compatibility risk, several solutions will be proposed. MATERIALS & METHODS : Observation of preparation and administration habits during two months and comparison of nurse habits versus references. Listing of the most utilized drugs and construction of physicochemical properties and compatibilities forms. Compatibility matrix based on the whole data collected is realized in order to match the unit needs. Finally, a whole day of prescriptions is chosen arbitrarily and investigated so as to identify situations at risk. RESULTS : 174 different combinations of drug have been noted during a period of 24 hours, 21 of them were incompatible (12%). Drugs administered on 24 hours were involved in about 58% of the incompatibilities recorded. Several answers have been proposed to reduce the incompatibility risk like separating acid and basic drugs, using double lumen catheter or isolating parenteral nutrition.
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Master Thesis
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Submitted on : Tuesday, November 27, 2012 - 3:59:16 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Saturday, December 17, 2016 - 4:21:09 PM


  • HAL Id : dumas-00757800, version 1
  • PPN : 165788275


Nathalie Neveu. Administrations parentérales en unité d'hématologie soins intensifs‎ : incompatibilités physico-chimiques et optimisations. Sciences pharmaceutiques. 2012. ⟨dumas-00757800⟩



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