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Master Thesis

Caractéristiques des patients présentant une hyponatrémie sévère en service de médecine : épidémiologie, clinique, étiologies et évolution

Abstract : aIntroduction : Hyponatremia is the most frequent electrolyte disorder and is associated with high morbi-mortality. Aim : To describe epidemiological, clinical, aetiological characteristics and evolution in medical in-patients with severe hyponatremia in a medicine department. Methods : A retrospective study has been conducted in the internal medicine department of the University Hospital of Grenoble. All the patients who had serum sodium < 120 mmol/l during their hospitalisation in the internal medicine department between January 1st of 2006 and May 31st of 2012 were included. Clinical and biological data have been raised. Studied parameters were age, sex, purpose of hospitalisation, comorbidities, treatment at admission, type of hyponatremia (admission hyponatremia or hospital acquired hyponatremia), symptoms, suspected mechanisms, aetiologies, and evolution. Results : Seventy two patients were included. The prevalence of hyponatremia < 120 mmol/l was 0,53 %. Sixty four patients came from their home. Sex ratio was 1. Median age was of 75,6 years. Hyponatremia was responsible for hospitalisation in 42 patients. Iatrogeny was the first aetiology (41/72). The most frequent drug association was system renine angiotensine aldosterone antagonists and thiazide diuretics(11/72). Outcome was severe (transfer to intensive care unit or death) for 18 patients. Prognosis was more severe in patients who had developed hyponatremia during their stay at the hospital (p < 0,0001). Conclusion : Our study shows the large number of severe hyponatremia preventable.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00769783
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Submitted on : Thursday, January 3, 2013 - 1:48:02 PM
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Béatrice De Guibert. Caractéristiques des patients présentant une hyponatrémie sévère en service de médecine : épidémiologie, clinique, étiologies et évolution. Médecine humaine et pathologie. 2012. ⟨dumas-00769783⟩

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