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Master Thesis

Qu'est-ce qu'un biomédicament en rhumatologie en 2013 ?‎ Étude épistémologique

Abstract : Biologic agents are increasingly used in rheumatology. However, they are not well known by general public. This work is about epistemology of biologics: understanding theirs origins, mechanisms and models, their unity and uniqueness. We first consider the prefix "bios" which is both reductionist and incredibly poetic. But it mainly belongs to the vocabulary of imagination. Physicians must keep that in mind to understand the fears of their patients and legislation. The variability in living things explains the distinction between biosimilars and generic drugs. How to make compatible these definitions and the fact that living organisms are unpatentable? Moreover, biologics are based on the model of "Self and not-self". This model is derived from the philosophical and psychoanalytic "self" of the XXth century. This self enables us to describe biological identity with more subjectivity and temporality than genetic identity. Thus, how to conceive autoimmune diseases and immunomodulation? How to help patients distinguish between the self, biological identity and the individual? At last, they are used according to principles of Evidence Based Medicine. This powerful tool has enabled great improvements. But we must know its limits. Medicine is a social science. Without experience, relational, subjectivity, doctor is reduced to a computer. Guidelines should not exonerate practitioner from his decision-making. This work helps to understand the origins of a therapeutic class, and invites the reader to reflect on his own medical practice.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Wednesday, October 9, 2013 - 3:06:10 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Friday, January 10, 2014 - 4:24:37 AM


  • HAL Id : dumas-00871349, version 1
  • PPN : 172219744


Myriam Muslmani Renard. Qu'est-ce qu'un biomédicament en rhumatologie en 2013 ?‎ Étude épistémologique. Médecine humaine et pathologie. 2013. ⟨dumas-00871349⟩



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