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Master Thesis

Prélèvement mammaire interne guidé par la lymphoscintigraphie‎ : la désescalade raisonnée du traitement de la chaîne mammaire interne ?

Abstract : Histological evaluation of the internal mammary chain (IMC) sentinel node in breast cancer patients remains a subject of discussion. The aim of this study was to determine the impact of routinely performed IMC sentinel node biopsy on the adjuvant treatments. All patients with biopsy proven breast cancer who underwent a sentinel node procedure between 2008 and 2012 were included in a retrospective study. If the removed sentinel node contained malignant cells or not, we determined if this altered the treatment plan when practising the current guidelines. In total, 114 of the 401 included patients showed IMC drainage on lymphoscintigraphy (28.4%). Exploration of the IMC was performed in 158 (39.4%) patients; in 154/158 (97.5%) exploration was successful. In 17/158 patients (10.8%) the IMC sentinel node was tumor positive. Macro and micrometastases were found in 14 and 3 patients, respectively. CMI node was positive in 6 cases (3.8%) without positive axillary node. The surgical removement suffered no complications. In the group of patients who underwent surgical exploration of the IMC, systemic treatment was changed in 3 cases (1.9%), radiotherapy treatment in 20/158 patients (12.6%). Radiotherapy treatment is altered in a small proportion of the patients; however, solid scientific evidence for this adjustment is lacking. Involvement of stadification with involvement with FDG PET/CT seems important, to reduce and select more precisely indications of surgical removement and IMC treatments.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00875322
Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, October 21, 2013 - 4:43:17 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Friday, April 7, 2017 - 2:19:26 PM

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  • HAL Id : dumas-00875322, version 1

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François Istasse. Prélèvement mammaire interne guidé par la lymphoscintigraphie‎ : la désescalade raisonnée du traitement de la chaîne mammaire interne ?. Médecine humaine et pathologie. 2013. ⟨dumas-00875322⟩

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