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Master Thesis

Pronostic obstétrical et fœtal des patientes atteintes de maladie de Crohn traitées par anti-TNFα pendant la grossesse. À propos d'une série rétrospective de 23 cas à l'hôpital Beaujon

Abstract : Obstetrical and Fetal prognosis of Crohn's disease women treated by anti-TNFα during pregnancy. A case report about 23 pregnancies in a French hospital. Objective: To report on the outcome of 23 cases of women affected by Crohn's disease and treated with anti-TNF-α drug during pregnancy, in order to determine the effect of this treatment on the disease and the pregnancy, and to establish the obstetrical and fetal prognosis of these women. Methods: A descriptive retrospective case study permits to identify 23 pregnancies from 2008 to 2012 in the BEAUJON's hospital, tertiary reference center of IBD, AP-HP, PARIS. Results: 18 women had a total of 23 pregnancies resulting in 5 miscarriages, 14 at-term and 4 preterm deliveries. The half of the women were treated by infliximab (n=11), and the other half by adalibumab (n=12). The treatment was stopped at the beginning of the third trimester in prevention of neonatal immunosuppression. The half of the 18 newborns is borned by cesarean, for obstetricals indications of which one for an acute fatty liver of pregnancy. 18 babies are borned, one baby died a few hours after the delivery for a metabolic acidosis. No malformation was found. Conclusions: The benefits of the anti-TNFα in maintaining remission in Crohn's disease women may outweigh to the risk of the exposure of the fetus to the drug, there is no increased risk tie to the treatment.
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https://dumas.ccsd.cnrs.fr/dumas-00875792
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Submitted on : Tuesday, October 22, 2013 - 5:20:53 PM
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  • HAL Id : dumas-00875792, version 1

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Vanessa Pinho. Pronostic obstétrical et fœtal des patientes atteintes de maladie de Crohn traitées par anti-TNFα pendant la grossesse. À propos d'une série rétrospective de 23 cas à l'hôpital Beaujon. Gynécologie et obstétrique. 2013. ⟨dumas-00875792⟩

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