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Master Thesis

Valeur diagnostique du protocole de scintigraphie double isotope Thallium-201 injecté au Stress / Technetium-99m injecté au repos dans l'imagerie de perfusion myocardique ultra rapide : comparaison avec l'angiographie coronaire

Abstract : Background: Recent advances in nuclear myocardial perfusion imaging (MPI) have provided possibility to use dual isotope protocol for high speed acquisition (DI-HS-MPI) with image quality and radiation dosimetry similar to those observed with a conventional single isotope protocol. So far, no study compares the results of DI-HS-MPI to invasive coronary angiography. Methods: Over 1-year period (May 2011 to April 2012), A total of 1366 patients received DI-HS-MPI. Patients with invasive coronary angiography (ICA) within 3 months and patients with low likelihood of coronary artery disease (CAD) to assess normalcy rate were included. The global summed stress score (SSS), summed rest score (SRS) were calculated and ICA were analyzed in a blinded manner to the results of MPI. The main end point was the evaluation of patient based diagnostic performance of DI-HS-MPI to detect or rule out significant CAD (>70% luminal diameter reduction). Results: Criteria were fulfilled by 214 patients (73 men, age 65 ± 12 years; ICA, n = 104; normalcy rate, n = 110). Exercise-test was performed in 36% of patients, pharmacological stress with dipyridamole in 48%, and dobutamine in 16%. Prevalence of angiography CAD was 75%. Average exam duration was 22.4 ± 4.5 min. Sensitivity was 94%, normalcy rate was 92%, and accuracy was 83% for detecting obstructive CAD. Conclusion: In this first comparison of DI-HS-MPI with ICA, we show a high accuracy for detection of angiographically documented CAD for this new camera technology and new high speed protocol.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00905781
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Submitted on : Monday, November 18, 2013 - 4:33:51 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Saturday, April 8, 2017 - 1:21:52 AM

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  • HAL Id : dumas-00905781, version 1

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Mélanie Leclère. Valeur diagnostique du protocole de scintigraphie double isotope Thallium-201 injecté au Stress / Technetium-99m injecté au repos dans l'imagerie de perfusion myocardique ultra rapide : comparaison avec l'angiographie coronaire. Médecine humaine et pathologie. 2013. ⟨dumas-00905781⟩

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