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Master Thesis

Reconnaissance biomoléculaire, comparaison de l'impact du soufre et de l'oxygène dans la liaison glycosidique

Abstract : Interactions between carbohydrates and proteins play a key role in many biological processes. Cell-cell interactions, cell communication and cell proliferation are examples of processes based on highly specific interactions between proteins and complex oligosaccharides. The synthesis of carbohydrates mimics crucial for the study and understanding of such recognition processes has therefore become increasingly popular over the last decades. In synthesis, thiol derivatives have several advantages. Thus, the combined nucleophilicity and chemical stability properties of a sulfhydryl group provide thiol carbohydrate analogs as excellent building blocks for glycosylation processes. This project aims to investigate the differences between naturally occurring oligosaccharides and their sulfur-analogs in biomolecular interactions with specific proteins. We herein disclose a convenient methodology to synthesize 1, 2 and 6 mannose thioanalogs. Such a strategy allows access to 1,2 and 1,6 linked dimannoside in the same time by glycosilation. We also want to introduce an inhibition study methodoly to test these compounds on a mannose specific lectin (Concanavalin A) using QCM methodology.
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Master Thesis
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Germain Fauquet. Reconnaissance biomoléculaire, comparaison de l'impact du soufre et de l'oxygène dans la liaison glycosidique. Chimie thérapeutique. 2011. ⟨dumas-00960710⟩

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