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Master Thesis

Don d’ovocytes à l’hôpital Cochin et à l’étranger : comparaison des pratiques et impact sur les issues de grossesse

Abstract : Background – Oocyte donation (OD) allows women with ovarian failure to have successful pregnancies. In France, since this technique is authorized only before the age of 43, many women seek cross border reproductive care. Our objective was to compare OD practices between Cochin hospital and several foreign centers, and to assess their impact on pregnancy outcomes. Methods – Between 2010 and 2013, 88 women benefited from an OD in Cochin and delivered in the maternity of their choice and 121 women benefited from an OD in a foreign center and then delivered in Port Royal maternity. We compared OD practices and pregnancy outcomes according to OD origin and pregnancy outcomes according to the type of pregnancy (singleton or multiple). Finally, we analyzed risk factors for preeclampsia. Results – Practices differed according to OD origin, especially regarding the number of embryos transferred, the age of the donor and multiple pregnancies rate. Both groups showed a high incidence of complications, especially in case of multiple gestations. Factors associated with preeclampsia were african origin (AOR=3.2[1.1-9.3]), primiparity (AOR=12.5[2.4-66.0]), duration of infertility ≤ 2 years (AOR=36.7[4.0-339.3]), age of the donor ≥ 35 years (AOR=5.0[1.6-16.1]) and multiple gestation (AOR=7.3[2.5-21.2]). Conclusion – OD is an independent risk factor of high risk pregnancy regardless of OD origin, while maternal age does not seem to be an aggravating factor. Since complications are more frequent in case of twin pregnancies, only one embryo should be transferred when the donor is young.
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Master Thesis
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Aurélie Rohfritsch-Vincent. Don d’ovocytes à l’hôpital Cochin et à l’étranger : comparaison des pratiques et impact sur les issues de grossesse. Médecine humaine et pathologie. 2013. ⟨dumas-01078659⟩



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