Skip to Main content Skip to Navigation
Master Thesis

Consultations d’oncogénétique pédiatrique : quelles indications et quelles pratiques dans un service spécialisé de cancérologie pédiatrique ? Enquête dans le centre spécialisé du CHU de Bordeaux en 2011-2012

Abstract : Background: Genetic predispositions to cancer in children are rare, with a proportion of 10%, currently accepted. The identification of such susceptibility is one of the "essential requirements" to improve the management of these patients. The call points that allow considering genetic predisposition to cancer should be specifically identified to make accurate indications. Objectives: Given the need to test first and foremost the children most at risk of predisposition, a tool to help children guidance may be useful in screening for risk factors in pediatric oncology service. The description and quantification of these genetic risk situations and their modality of care will help to create this tool. Methods: This study was conducted in the specialized center of Bordeaux University Hospital on all children in care with a diagnosis of cancer between 2011 and 2012. The chosen risk factors, included age less than one year when diagnosed, multifocal lesions, the type of cancer presented (specific syndrome predisposition), having a secondary tumor, family history of cancer and finally the call of the clinical examination points. Results: 223 patients with a diagnosis of cancer were treated at specialized center of Bordeaux University Hospital between 2011 and 2012. For 76 patients (33.9%), there was at least one risk factor for genetic susceptibility to cancer. The two risk factors most frequently encountered were the age of less than one year at diagnosis (26 or 34.2%) and a family history of cancer (37 or 48.7%). For 65.8% of patients with predisposing risk, there was only a single risk factor. A total of 23 patients were treated in an oncogenetic unit, which corresponds to 30% of the patients with risk factors. These children were primarily patients with multifocal disease or multiple risk factors. Conclusion: There is a large proportion (33.9%) of patients for whom an oncogenetic consultation would be necessary. This fully justifies the establishment of a dedicated pediatric cancer genetic consultation. The oncogenetic consultations were conducted in patients with visible criteria for clinicians. A systematic data collection file to put in the patient records to improve access to this course of care, would facilitate the screening of patients at risk.
Document type :
Master Thesis
Complete list of metadata

Cited literature [97 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01103420
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, January 14, 2015 - 4:37:40 PM
Last modification on : Wednesday, August 23, 2017 - 4:31:17 PM
Long-term archiving on: : Saturday, September 12, 2015 - 6:22:44 AM

Identifiers

  • HAL Id : dumas-01103420, version 1

Collections

Citation

Stéphanie Gourdon. Consultations d’oncogénétique pédiatrique : quelles indications et quelles pratiques dans un service spécialisé de cancérologie pédiatrique ? Enquête dans le centre spécialisé du CHU de Bordeaux en 2011-2012. Médecine humaine et pathologie. 2014. ⟨dumas-01103420⟩

Share

Metrics

Record views

127

Files downloads

479