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Master Thesis

La nécrolyse épidermique toxique : le suivi des séquelles sur une série de cas au CHU de Bordeaux

Abstract : Introduction:Toxic epidermal necrolysis (TEN) is a rare but extremely serious disease, with different clinical forms, with a high mortality rate during the acute phase and frequent long-term complications. The objectives of the study were to assess long-term consequences of TEN and patients’ outcome in 2014. Methods:The population under study included all patients admitted for medicine-induced TEN from January 2007 to April 2013, in the Burn unit and/or the Dermatology departments of the Bordeaux university hospitals. Data were collected on a standardized form (taking into account the national recommendations for diagnosis and treatment and the form used by the Regiscar study), from hospital medical files at the acute phase and for those followed as out- or inpatients at the Bordeaux hospitals; to complete these data, a questionnaire was sent in 2014 to the patients and their general practitioners. Results:Twenty-one cases of TEN were included in the study: 12 cases of Lyell’s syndrome, 6 of Stevens-Johnson syndrome (SJS) and 3 of TEN-SJS overlap form. Outcome in 2014 was evaluated through return from questionnaires for 20 patients. Four patients died, of whom 2 from complications of TEN. Most common complications were cutaneous (70%), followed by psychological (60%) and ocular (50%) ones, the latter being the most serious. Since the acute phase of TEN, nine patients were followed for complications by at least one physician (dermatologist, ophthalmologist, psychiatrist, etc.); 8 had been hospitalized for complications and 3 had repeated eye surgical treatment. Conclusion:TEN can induce long-term complications, which can have important consequences on the daily life. This stresses the importance of multidisciplinary follow-up care for early detection and optimal management of complications.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Tuesday, January 20, 2015 - 10:29:06 AM
Last modification on : Wednesday, August 23, 2017 - 4:34:08 PM
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  • HAL Id : dumas-01105303, version 1



Bénédicte Raspaud. La nécrolyse épidermique toxique : le suivi des séquelles sur une série de cas au CHU de Bordeaux. Sciences pharmaceutiques. 2014. ⟨dumas-01105303⟩



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