Skip to Main content Skip to Navigation
Master Thesis

L'hyperuricémie dans l'insuffisance cardiaque : prévalence, physiopathologie et implications cliniques

Abstract : Background: Hyperuricemia plays a deleterious role in many cardiovascular pathology. In heart failure, studies showed an association between hyperuricemia and morbi-mortality. The mechanism involve an overactivation of xanthine oxydase and an increased of reactive oxygene species. Studies show that the inhibitor of XO improves FEVG and the survival in patient with heart failure and hyperuricemia. Objectives-Methods: A retrospective study of 174 patients with heart failure and an average FEVG of 26%, evaluate the prevalence, the implication and the prognosis of hyperuricemia in heart failure. Results: The uricemia average is 451μmol/l. The prevalence is 53%. Uricemia is higher in the presence of cardiovascular risk factor including the active smoking (p 0.07), diabetes (p 0.2), HTA (p 0.3), male (p 0.03). There is a strong negative correlation with BMI (coeff corr – 0.9). Moreover, there is a correlation of uricemia with NYHA class (p 0.003), VE/VCO2 (p 0.01), VO2max and FEVG (coeff corr -0.97). Concerning the prognosis, hyperuricemia is associated with an increased risk of rehospitalization (RR 1.6, p <0.0001) and an increased risk of mortality (p 0.02, RR 1.6). Conclusions: The prevalence of hyperuricemia is high. Hyperuricemia is a prognostic factor of morbi-mortality and is associated with the factor of gravity (FE, NYHA, pente VE/VCO2) in heart failure. Others studies are needed to define a prognostic threshold of uricemia in heart failure and a therapeutic threshold by the XO inhibitors.
Document type :
Master Thesis
Complete list of metadata

Cited literature [75 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01114526
Contributor : Université Paris Descartes - Scd <>
Submitted on : Monday, February 9, 2015 - 3:25:50 PM
Last modification on : Friday, October 23, 2020 - 4:42:52 PM
Long-term archiving on: : Saturday, September 12, 2015 - 10:12:19 AM

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

  • HAL Id : dumas-01114526, version 1

Citation

Maria El Aissaoui. L'hyperuricémie dans l'insuffisance cardiaque : prévalence, physiopathologie et implications cliniques. Médecine humaine et pathologie. 2014. ⟨dumas-01114526⟩

Share

Metrics

Record views

656

Files downloads

7886