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Master Thesis

Performance diagnostique du génotypage rhésus D fœtal par prise de sang maternelle au premier trimestre de la grossesse

Abstract : Background: Non-invasive prenatal determination of the fetal rhesus D (RHD) status can be useful in the management of pregnancies of RHD negative women. It allows the identification of pregnancies at increased risk of immunization. Nevertheless, few studies have assessed the diagnostic accuracy of the RHD fetal genotyping in the first trimester of pregnancy. Methods: A systematic review, with a meta-analysis, was performed. Then we assessed the performance of the first trimester RHD fetal genotyping in an original retrospective study. Results: Fifteen trials were included (1328 patients) in the meta-analysis. The overall sensitivity was 97.3% (IC95 : 95.9 – 98.3). The overall specificity was 91.1% (IC95 : 86.9 – 94.0). In our retrospective study, 416 pregnancy outcomes were analyzed : the sensitivity was 100%, the specificity was 95.5%. Conclusion: Our data demonstrate that fetal RHD genotyping can accurately be determined in the first trimester of pregnancy.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01114621
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Submitted on : Monday, February 9, 2015 - 4:27:08 PM
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  • HAL Id : dumas-01114621, version 1

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Alexandre Vivanti. Performance diagnostique du génotypage rhésus D fœtal par prise de sang maternelle au premier trimestre de la grossesse . Médecine humaine et pathologie. 2014. ⟨dumas-01114621⟩

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