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Master Thesis

Prescription des inhibiteurs de la pompe à protons chez les sujets âgés : adéquation aux recommandations

Abstract : The proton pump inhibitors (PPIs) are widely prescribed in France, especially in patients over 65 years. In 2011, their prescriptions accounted for 725 million euros, and 75% of the prescriptions were from GPs.
The objective of this study was to assess compliance of prescriptions with the recommendations in elderly patients. This is a prospective and descriptive survey for 2 years, including outpatients treated with PPI. Data were collected from medical files and from a questionnaire sent to GPs.
216 patients, mean age 85 years, were included. 48% of prescriptions were off‐label, and their main indications were: prevention of gastroduodenal lesions under antiplatelet, AVK, or corticosteroid (23.9%), anemia without endoscopic exploration (12%), epigastric pain or dyspepsia (8.6%). Only 40.7% of patients had an upper gastrointestinal endoscopy before the introduction of PPI, as recommended in older patients.
It is up to each physician to assess the risk / benefit ratio of each PPI prescription, but a part of unjustified prescriptions could be avoided.
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Master Thesis
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Submitted on : Monday, May 4, 2015 - 11:11:52 AM
Last modification on : Wednesday, January 13, 2021 - 12:21:00 PM
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  • HAL Id : dumas-01148193, version 1


Claire Schönheit. Prescription des inhibiteurs de la pompe à protons chez les sujets âgés : adéquation aux recommandations. Médecine humaine et pathologie. 2013. ⟨dumas-01148193⟩



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