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Master Thesis

Recherche de parasites intestinaux, communément associés à un stade d’immunodéficience chez l’Homme, dans des populations de grands singes sauvages infectés ou non par le virus de l’immunodéficience simienne (SIV)

Abstract : African nonhuman primates are naturally infected with various simian immunodeficiency virus (SIV) that have crossed the species barrier on several occasions and generated human immunodeficiency virus (HIV). Unlike HIV which causes in humans, acquired immunodeficiency syndrome (AIDS) and has already caused millions of deaths, the SIV was not pathogenic in its natural host. However, two studies on habituated chimpanzees challenges this paradigm by demonstrating a AIDSlike in animals infected with SIV. To answer the question of pathogenicity of SIV in wild apes in Cameroon, we investigated the presence in their faeces of cryptosporidium and microsporidia, intestinal parasites associated with a AIDS in humans. The results indicated the presence of these parasites, but we have not been able to show a direct relationship between SIV status of the animal and parasite contamination. We also found a high genetic diversity among microsporidia amplified. This study assessed the feasibility and limitations of research parasitic infections in wild apes and paved the way for future research.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01200980
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Christelle Butel. Recherche de parasites intestinaux, communément associés à un stade d’immunodéficience chez l’Homme, dans des populations de grands singes sauvages infectés ou non par le virus de l’immunodéficience simienne (SIV). Sciences du Vivant [q-bio]. 2012. ⟨dumas-01200980⟩

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