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Master Thesis

Formes graves de chikungunya : étude descriptive des patients hospitalisés en réanimation aux CHU de Pointe-à-Pitre et de Fort-de-France au cours de l'épidémie de 2014

Abstract : Background. The first Chikungunya fever epidemic occurred recently in the Caribbean and Americas. However, data on severe forms and the need and frequency for ICU admission are scarce. Methods. Patients with laboratory-confirmed acute Chikungunya virus infection (CHIKV) admitted to the ICUs of the two main the French West Indies islands, between April and September 2014 in Guadeloupe, and between February and September 2014 in Martinique, were included in this observational study. Findings. The cohort consisted of 65 patients, median age 63 years (52-70). Their median Simplified Acute Physiology Score II at admission was 39 (28-54). Twenty-seven (41.5%) patients had exacerbations from a previous underlying disease. Seven (10.7%) had sepsis-like manifestations without any other clinically or microbiologically documented infection. Six patients (9.2%) had Guillain-Barré syndrome, and four (6.1%) had possible encephalitis. Overall hospital mortality was 27.7%. Interpretation. Although usually benign, CHIKV infection can be severe and result in patients’ admission to the ICU. Most patients with CHIKV infection who required ICU admission had a preexisting comorbidity and their medical condition had deteriorated after the onset of CHIKV infection. In some patients however, particularly those with Guillain-Barré syndrome, encephalitis and sepsis-like syndrome, the occurrence of such severe manifestations could be considered as a direct consequence of CHIKV. In areas where a CHIKV epidemic occurs, physicians should be aware of its potential severity.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01214734
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Submitted on : Monday, October 12, 2015 - 9:37:54 PM
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Laura Crosby. Formes graves de chikungunya : étude descriptive des patients hospitalisés en réanimation aux CHU de Pointe-à-Pitre et de Fort-de-France au cours de l'épidémie de 2014. Médecine humaine et pathologie. 2015. ⟨dumas-01214734⟩

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