Skip to Main content Skip to Navigation
Master Thesis

Les issues maternelles et foetales de la prolongation de la maturation cervicale par misoprostol 25 microgrammes en intra-vaginal jusqu'à 48 heures

Abstract : Objectives : To compare the maternal and neonatal outcomes of the extension of intravaginal misoprostol 25 µg for cervical ripening at 48 hours to 24 hours. Methods : A comparative and retrospective study has been realized to the CHI Poissy Saint-Germain-en-Laye. In the first group, the misoprostol is used with a posology of 25µg every four hours to a maximum of four doses. At the end of the 24 hours, the induction of labor with ocytocine is realized. In the second group, the same posology is used. If after 24 hours of cervical ripening, the score of bishop is still lower than 6, there is an extension of the cervical ripening till 48 hours. Results and conclusion : A hundred and ninety-six patients are included in the study : 124 received the misoprosol during 24 hours and 72 received the misoprostol during 48 hours. The rate of caesarian is not significantly different between the two groups (28.3% versus 26.4%, p=0.86). The rate of postpartum hemorrhage isn’t significantly different (4.8% versus 4.2%, p=1). The neonatal outcomes are not significantly different between the two groups. The low 5-minutes Apgar score (<7) between "cervical ripening 24 hours" and "cervical ripening 48 hours" is respectively 4 % versus 1.3 %, p=0.42; the pH lower than 7.10 in the birth is respectively 2.4 % versus 4.1 %, p=0.66; the admission to neonatal intensive care unit is respectively 2.4 % versus 6.9 %, p=0.14; the meconium aspiration syndrome is respectively 1.6 % versus 0 %, p=0.53. The maternal and neonatal outcomes are not significantly different between the two groups.
Complete list of metadatas

Cited literature [32 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01219389
Contributor : Uvsq Bibliothèques Universitaires <>
Submitted on : Thursday, October 22, 2015 - 3:40:00 PM
Last modification on : Friday, January 10, 2020 - 3:42:28 PM
Long-term archiving on: : Friday, April 28, 2017 - 5:35:41 AM

Identifiers

  • HAL Id : dumas-01219389, version 1

Citation

Rebecca Bouër. Les issues maternelles et foetales de la prolongation de la maturation cervicale par misoprostol 25 microgrammes en intra-vaginal jusqu'à 48 heures. Gynécologie et obstétrique. 2015. ⟨dumas-01219389⟩

Share

Metrics

Record views

119

Files downloads

169