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Master Thesis

Diagnostic des lésions mammaires non-palpables : l’approche écho-cytologique : l’expérience de l’Institut Curie sur une série de 3865 lésions ponctionnées sous guidage échographique

Abstract : Our study assessed the diagnostic performance of ultrasound (US)-guided fine needle aspiration (USFNA) in non- palpable breast lesions (NPBLs) and correlations between ultrasound, cytological and histological presentations of underscored (i.e malignant BI-RADS 3) and overscored (i.e benign BIRADS 4C and 5) NPBLs. Between 2003 and 2007, 3865 consecutive USFNA of NPBLs were performed and recorded at the Institut Curie. Clinical data, breast-ultrasound, cytology and pathology records for each NPBL were retrieved and analyzed. USFNA's sensitivity, specificity were respectively 0.93 (95% CI =[0.91,0.94) and 0.97 (95% CI = [0.96,0.98]). The best diagnostic performance was found in under50-year old patients and low BI-RADS categories.High-grade invasive carcinomas and specific types of carcinomas, represented most underscored NPBLs and were easily diagnosed at USFNA: in these cases USFNA alone can suffice to establish a diagnosis. Performance was lowest in cancers with very low mitotic counts, and among over-scored NPBLs, in epithelial and fibrous proliferations, intraepithelial proliferations, papillomas and benign tumors. These categories represented most over-scored NPBLs.These presented specific US features of shape, ultrasound pattern and posterior US-beam transmission to identify them. We therefore suggest using USFNA and core-needle biopsy in conjunction in higher BI-RADS categories, especially when such specific findings are found before biopsy.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01222334
Contributor : Université Paris Descartes - Scd <>
Submitted on : Thursday, October 29, 2015 - 4:57:05 PM
Last modification on : Friday, October 23, 2020 - 4:42:51 PM
Long-term archiving on: : Friday, April 28, 2017 - 6:34:10 AM

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  • HAL Id : dumas-01222334, version 1

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Josep Anton Farras Roca. Diagnostic des lésions mammaires non-palpables : l’approche écho-cytologique : l’expérience de l’Institut Curie sur une série de 3865 lésions ponctionnées sous guidage échographique. Médecine humaine et pathologie. 2015. ⟨dumas-01222334⟩

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