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Master Thesis

Implication du facteur XIII de la coagulation dans le maintien d'une grossesse

Abstract : Factor XIII is an essential protein of the coagulation system: it enables the stabilization of newly formed fibrin clot by protecting the clot of a rapid removal by the fibrinolysis system. Factor XIII is a zymogen which will form two subunits after cleavage: FXIII-A, which is the active form, and FXIII-B. It was identified in implantation tissue macrophages, uterine histiocytes and placenta, suggesting its involvement in pregnancy. Factor XIII is essential for the maintenance of pregnancy, in fact, severe factor XIII deficiency can lead to hemorrhagic bleeding or recurrent miscarriage in the first trimester for patients without replacement therapy. Factor XIII is a highly polymorphic protein, with no less than 10 polymorphisms encoding the subunit A, one of them (VAL34LEU) is present in nearly 20% of Europeans. This polymorphism is associated with a modification of structure of the fibrin clot. These polymorphisms may well affect the action of factor XIII. Objective To determine whether there is a significant relationship between the presence of certain polymorphisms coding for factor XIII and patients with recurrent spontaneous abortion. Methods Comparison of the frequency of certain polymorphisms of factor XIII in 288 patients with a history of witnesses 3 miscarriages repeatedly to a control group of 54 patients without a history of recurrent miscarriage using ARMS method. Results and conclusion The analysis of the different populations genotypes shows that the Y204F polymorphism is more frequent in the population of women with a history of recurrent miscarriage. Y204F is a risk factor for recurrent miscarriage.
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Submitted on : Thursday, November 12, 2015 - 3:24:45 PM
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  • HAL Id : dumas-01228051, version 1



Cynthia Daou. Implication du facteur XIII de la coagulation dans le maintien d'une grossesse. Gynécologie et obstétrique. 2015. ⟨dumas-01228051⟩



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