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Master Thesis

Escherichia coli producteur de BLSE chez l’enfant : étude rétrospective de 2009 à 2013 au CHU de Grenoble, recherche de facteurs de risque et de facteurs de gravité

Abstract : Objectives. The objective of this study is to investigate the epidemiology extended-spectrum-lactamase producing Escherichia coli (E. coli BLSE) infections in children. Secondary objectives were to study antimicrobial resistance and to look for risk and gravity factors. Methods. It is a descriptive epidemiology study design. The population is all the children aged less than 15 years who consulted at the emergency ward or were hospitalized in a pediatric unity in the university hospital of Grenoble, who had at least one positive sample to E. coli BLSE between the 15th of june 2009 and the 31st of December 2013. Results. There were 47 cases of infection and 34 cases of colonisation. 80% of infections were urinary infections, included pyelonephritis and cystitis. Neonates represented 16% of global population. There was no antibiotic resistance to penems. Resistance rates to amikacin, cotrimoxazole, ciprofloxacin and cefoxitin are stable, while resistance rate to gentamycin is increasing. The age, urinary introduction, and prematurity antecedent may be risk factors of infection, while a high number of positive samples, multiple location of the pathogenic germ, digestive introduction, immunodepression and leukopenia may be gravity factors. Conclusions. The number of children infections to E. coli BLSE is increasing in the university hospital of Grenoble, with mainly urinary and neonatal infections. Identification of high-risk patients is a major challenge.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01231199
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Submitted on : Thursday, November 19, 2015 - 4:26:07 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:18 AM
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  • HAL Id : dumas-01231199, version 1

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Gaëlle Béal. Escherichia coli producteur de BLSE chez l’enfant : étude rétrospective de 2009 à 2013 au CHU de Grenoble, recherche de facteurs de risque et de facteurs de gravité. Médecine humaine et pathologie. 2015. ⟨dumas-01231199⟩

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