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Master Thesis

Extra-Corporeal Membrane Oxygenation durant la transplantation pulmonaire : causes et complications. Analyse d'un recueil prospectif de l'hôpital Foch de 2012 à 2014

Abstract : Extracorporeal Membrane Oxigenation (ECMO) has progressively replaced cardiopulmonary bypass in providing cardiopulmonary support to patients undergoing lung transplantation. The objective of the current study was to analyze the causes and complications related to ECMO on lung transplants patients at the Foch Hospital. The study group consisted of 160 patients who underwent double lung transplantation between 2012 and 2014. 84 patients did not receive ECMO while 76 patients received ECMO due to hemodynamic (50%), respiratory causes (25%) or both (25%). 48 of the 76 patients required “short-duration ECMO” while 28 had “long-duration (per and postoperative) ECMO” if hypoxemia persisted following the surgery.Patients with preoperative pulmonary hypertension or idiopathic pulmonary fibrosis were more often transplanted while receiving ECMO. In-hospital mortality was 2 % for patients who did not receive ECMO and 4 % for the “short-duration ECMO” group (p = 0,62), but was higher (7%) in patients who received “long-duration ECMO” (p = 0,007). Median in-hospital stay was 29,5 days [23 – 38] and 31 days [24 – 55] for the “no ECMO” and “short-duration ECMO” groups, respectively (p = 0,11) but was higher 49 days [30 - 45] in the “long-duration ECMO” group (p < 0,001). The incidence of lower limb complications was 2 % for “no ECMO” and “short-duration ECMO” groups (p = 1), but was 18 % for the “long-duration ECMO” group (p = 0,023). The results of the study indicate that the rate of complications of patients undergoing short-duration ECMO is similar to patients not requiring cardiopulmonary support but indicates that is worse in patients who require postoperative ECMO.
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Submitted on : Monday, November 30, 2015 - 6:10:48 PM
Last modification on : Saturday, November 23, 2019 - 9:35:32 PM
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Julien Fessler. Extra-Corporeal Membrane Oxygenation durant la transplantation pulmonaire : causes et complications. Analyse d'un recueil prospectif de l'hôpital Foch de 2012 à 2014. Sciences du Vivant [q-bio]. 2015. ⟨dumas-01235847⟩

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