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Master Thesis

Devenir neurologique d’une cohorte d’enfants porteurs d’une malformation anévrismale de la veine de Galien et détermination de facteurs pronostiques clinico-radiologiques

Abstract : Aneurysmal malformations of the vein of Galen represent nearly half of paediatric cerebral vascular malformations. Catheterization treatment has improved vital and neurological prognoses but the long-term clinical assessment is still imprecise. The main objective of this study is to evaluate the neurological outcome of a consecutive cohort of children with arteriovenous malformation of the vein of Galen, treated at the Bicêtre hospital. The secondary objectives are to determine clinical and radiological factors linked to a poor neurological prognosis. Fifty-two French-speaking children, born between 1st January 2004 and 31 December 2009, were included in the study. Telephone contact was used to assess their neurological condition, using the Bicêtre Outcome Score, modified Rankin Scale and Rivermead post-concussion questionnaire. Retrospective analysis of the dossiers led to the identification of factors linked to a poor neurological prognosis. The neurological examination was normal or subnormal in 38 % of the children and 25 % had moderate to severe neurological symptoms. The mortality rate was 37 % but 31 % were in palliative care. A Bicêtre neonatal score of less than 12 is a factor linked to a poor neurological prognosis (p = 0.02). Severe neonatal cardiopulmonary occurrences and encephalomalacy are responsible for excessive perinatal mortality. Ventriculomegaly is common in these children but symptomatic hydrocephaly seems to be correlated with the neurological prognosis. Eventually, 38 % of the children in our cohort had a good cognitive level but 12 % showed severe psychomotor retardation and 33 % died during the perinatal period.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01253089
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Submitted on : Friday, January 8, 2016 - 4:06:21 PM
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  • HAL Id : dumas-01253089, version 1

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Hélène Taffin. Devenir neurologique d’une cohorte d’enfants porteurs d’une malformation anévrismale de la veine de Galien et détermination de facteurs pronostiques clinico-radiologiques. Médecine humaine et pathologie. 2015. ⟨dumas-01253089⟩

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